HDR/EBRT Combination Therapy Challenges
Differences in Imaging and Treatment Delivery Complicate Dose Summation
Max Doses Don't Overlap, Leading to Conservative Dose Estimates
Due to the use of an applicator in HDR therapy, the max dose often doesn't overlap between HDR and EBRT images. This can cause clinicians to over-estimate the dose delivered to healthy tissue when planning combined therapy, leading to cancer being targeted with less radiation than could be safely possible.1
1. Mallory Sherrill et. al, "Assessing the Clinical Viability of Contour Based Hybrid Deformable Registration (CBH DIR) through Analysis of Spatial Dose Mapping of Per Structure High Dose Regions and Contour Transfer Fidelity for GYN HDR/EBRT Combined Treatment," International Journal of Radiation Oncology, Biology, Physics vol 123, 1 (2025). https://doi.org/10.1016/j.ijrobp.2025.06.2362.
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MIM ComboTherapy GYN HDR/EBRT
Your Visual Advantage in HDR/EBRT Combination Therapy
Visual Understanding of Dose Overlap Enables Confident Treatment Decision-Making
Precise Assessment of Summed Doses with 3D Dose Review
MIM ComboTherapy GYN HDR/EBRT provides three-dimensional dose summation with biological effective dose (BED) and equivalent dose in 2-Gy fractions (EQD2) for precise assessment of summed doses.More Clarity with Hotspot Overlap Visualization
Precise dose summation is designed to increase clarity in hotspot overlap, highlighting the areas of highest dose accumulation between plans.Confident Deformable Image Registrations
Quantitative and qualitative evaluation tools help you validate the accuracy of the deformable image registrations used to sum the doses from HDR and EBRT treatments.Resources
Research
Abstract
Assessing the Clinical Viability of Contour Based Hybrid Deformable Registration (CBH DIR) through Analysis of Spatial Dose Mapping of Per Structure High Dose Regions and Contour Transfer Fidelity for GYN HDR/EBRT Combined Treatment
International Journal of Radiation Oncology, Biology, Physics
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