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Y90 Microsphere Dosimetry


Image Reconstruction

Siman W, Mikell JK, Kappadath SC. Practical reconstruction protocol for quantitative (90)Y bremsstrahlung SPECT/CT. Med Phys 2016; 43(9):5093-5103.


Willowson KP, Tapner M, The QUEST Investigator Team, Bailey DL. A multicentre comparison of quantitative Y90 PET/CT for dosimetric purposes after radioembolization with resin microspheres. Eur J Nucl Med Mol Imaging 2015; 42:1202-1222.




Nelson AS, Swallen A, Arpidone M, et al. Dosimetry for Yttrium-90 MicrosphereBrachytherapy 2018 (White Paper).


Nelson AS, Swallen A, & Dewaraja YK. Evaluation of a voxel-based yttrium-90(Y-90) dose calculation method for Bremsstrahlung SPECT using a liver phantom. J Nucl Med 2016; 57(Suppl 2):306 (Oral Presentation at SNMMI 2016).




Kappadath SC, Mikell J, Balagopal A, et al. Hepatocellular Carcinoma Tumor DoseResponse After 90Y-radioembolization With Glass Microspheres Using 90Y-SPECT/CT-Based Voxel Dosimetry. Int J Radiation Oncol Biol Phys 2018; 102(2): 451-461.





Post-Op Y90 Voxel-Based Dosimetry: PET

Maughan NM, Garcia-Ramirez J, Arpidone M, et al. Validation of Post-Treatment PET-Based Dosimetry Software for Hepatic Radioembolization of Yttrium-90 Microspheres. Med Phys 2019; 46(5):2394-2402.


Nelson AS, Swallen A, Arpidone M, et al. Dosimetry for Yttrium-90 Microsphere Brachytherapy 2018 (White Paper).


Nelson AS, Swallen A, & Dewaraja YK. Evaluation of voxel-based yttrium-90 (Y-90) dose calculation methods for Y-90 PET using a liver phantom. J Nucl Med 2016; 57(Suppl 2):1424.



Fowler KJ, Maughan NM, Laforest R, et al. PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response. Cardiovasc Intervent Radiol 2016; 39:855-864.



Liver Segmentation

Horvat M, Nelson AS, Pirozzi SD. Time Savings of a Multi-Atlas Approach for Liver Segmentation. J Nucl Med. 2014; 55 (Supplement 1):1523.


Horvat M, Nelson AS, Piper JW, Traughber B, Faulhaber P. Time savings for liver volume generation: Comparison of manual and deformable segmentation methods. J Nucl Med. 2012; 53 (Suppl 1):2264.



Lung Shunt

Allred JD, Niedbala J, Mikell JK, Owen D, Frey KA, Dewaraja YK. The value of 99mTc-MAA SPECT/CT for lung shunt estimation in 90Y radioembolization: a phantom and patient study. EJNMMI Research 2018; 8:50.


Yu N, Srinivas SM, DiFilippo FP, Shrikanthan S, Levitin A, McLennan G, Spain J, Xia P, Wilkinson A. Lung Dose Calculation with SPECT/CT for 90Yttrium Radioembolization of Liver Cancer. IJROBP 2013; 85(3):834-839.



Deformable Registration

Lamba N, Kruzer A, Pirozzi S, Ginsburg S, Nelson AS. Evaluation of an Intensity-based Deformable Registration Algorithm for the Generation of Liver Volumes on Post Y90 PET/CT. Accepted for presentation at AAPM 2018.


Nelson AS, Duchateau M, Piper JW, Verellen D, De Ridder M. Evaluation of a Free-Form Intensity Based Deformable Registration Method Using the POPI Model. Med Phys 2014; 41:202.


Pirozzi S, Piper J, Nelson A, Duchateau M, Verellen D, De Ridder M. A Novel Framework for User-Intervened Correction of Deformable Registration. IJROBP 2013; 87(2):S144.



Dose Calculation

Nelson AS, Swallen Dewaraja Y. Evaluation of a voxel-based yttrium-90 (Y-90) dose calculation method for Bremsstrahlung SPECT using a liver phantom. J Nucl Med 2016; 57 (Suppl 2):306 (Oral Presentation).


Nelson AS, Swallen A, Dewaraja Y. Comparison of voxel-based yttrium (Y-90) dose calculation methods for Y-90 PET using a liver phantom. J Nucl Med 2016; 57 (Suppl 2):1424.


Maughan NM, Garcia-Ramierez J, Arpidone M, Swallen A, LaForest R, Goddu SM, Parikh PJ, Zoberi JE. Commissioning of Post-Treatment PET-Based Dosimetry Software for Hepatic Radioembolization with Ytrrium-90 Microspheres. May-June 2017; 16(3):S21.




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